BACKGROUND The development of graphical / visual presentation of the etiology of cancer caused by environmental stress is a process that requires incorporating biological interactions complex between xenobiotics in living and working environment with the gene (gene-environment interactions) and the mechanisms of certain diseases based on genomic and non-genomic in life organism. Traditionally, presentation causal relationships including statistical association between exposure to a xenobiotic and diseases corrected for the effect of potential confounders.
METHOD In HENVINET FP6 project, we aim to consider the agent together all the known and the mechanisms involved in the development of selected types of cancer. Selection of the type of cancer to the causal diagram based on the corpus of data available and reported relative risk (RR). In establishing a causal diagram complexity of interactions between xenobiotics considered as a priority in the interpretation of the risk of cancer. In addition, gene-environment interactions such as polymorphism gene inserted to repair and Phase I and II enzymes involved in the metabolism of xenobiotics and their elimination. Information about the possibility of age or gender vulnerability is also included.
Diagram user friendly thanks to access to the stage for an information packet and referring to the relevant literature and a glossary of terms. Diagram cover both the chemical and physical agents (ionizing and non-ionizing radiation) and provide basic information about the strength of the relationship between the types of exposures and cancer risk were reported by human studies and is supported by mechanistic studies. Causal diagram HENVINET developed in the project is a valuable source of information for professionals working in the field of environmental health and epidemiology, and as an educational material for students.
Cancer risk and the complexity of the interactions between environmental and host factors: HENVINET interactive diagrams as simple tools for exploring and understanding the scientific evidence.
BACKGROUND Cancer risk results from a complex interaction of environmental exposure with polymorphisms of genes are inherited, genetic load collected during development and capacity non-genomic response to environmental insults. In order to adopt preventive measures are effective and relevant regulatory measures, a comprehensive investigation of the etiology of cancer is very important. Variations and fluctuations in the incidence of cancer in the human population does not reflect the policy of environmental pollution or population distribution of genetic polymorphisms known to be associated with an increased risk of cancer.
Tools that can be used in such comprehensive research, including molecular biology applied to field studies, requires a shift methodological reductionism that has been used until recently as a basic axiom in the interpretation of data. The complexity of interactions between cells, genes and environment, the resonance of living matter with the environment, can be synthesized by biological systems. In the philosophy HENVINET project followed in order to develop interactive causal diagram for cancer investigation with a possible etiology in environmental exposures.
Urea for molecular biology, 99.5%
21113
Sisco Laboratories
500 Gms
EUR 6.5
Description: Part A
Xylene for molecular biology, 99.5%
45122
Sisco Laboratories
250 ml
EUR 2.81
Description: Part A
Glycine for molecular biology, 99.5%
64072
Sisco Laboratories
100 Gms
EUR 1.64
Description: Part A
Acetone for molecular biology, 99.8%
27498
Sisco Laboratories
500 ml
EUR 3.76
Description: Part A
Methanol for molecular biology, 99.5%
96446
Sisco Laboratories
500 ml
EUR 6.23
Description: Part A
Formamide for molecular biology, 99.5%
30349
Sisco Laboratories
500 ml
EUR 5.82
Description: Part A
Imidazole for molecular biology, 99.5%
61510
Sisco Laboratories
25 Gms
EUR 5.47
Description: Part A
Chloroform for molecular biology, 99.8%
96764
Sisco Laboratories
100 ml
EUR 3.08
Description: Part A
Triethylamine for molecular biology, 99.5%
55221
Sisco Laboratories
500 ml
EUR 4.11
Description: Part A
Ficoll 400® for molecular biology
45460
Sisco Laboratories
5 Gms
EUR 15.6
Description: Part B
Agarose UltraPhor for molecular biology
27813
Sisco Laboratories
10 Gms
EUR 46.5
Description: Part B
Boric Acid for molecular biology, 99.5%
22311
Sisco Laboratories
250 Gms
EUR 4.04
Description: Part A
2-Mercaptoethanol ?For Molecular Biology
MB041-100ML
EWC Diagnostics
1 unit
EUR 9.02
Description: 2-Mercaptoethanol ?For Molecular Biology
2-Mercaptoethanol ?For Molecular Biology
MB041-500ML
EWC Diagnostics
1 unit
EUR 26.47
Description: 2-Mercaptoethanol ?For Molecular Biology
Vitamin B12 for molecular biology, 97%
77472
Sisco Laboratories
250 Mg
EUR 5.78
Description: Part B
Triton X-100 for molecular biology
64518
Sisco Laboratories
100 ml
EUR 6.02
Description: Part A
MOPS Buffer for molecular biology, 99%
66043
Sisco Laboratories
25 Gms
EUR 10.28
Description: Part B
ACES Buffer for molecular biology, 99.5%
27907
Sisco Laboratories
5 Gms
EUR 5.4
Description: Part B
Agarose Low EEO for molecular biology
36601
Sisco Laboratories
10 Gms
EUR 5.1
Description: Part B
PIPES Buffer for molecular biology, 99%
49159
Sisco Laboratories
100 Gms
EUR 26.03
Description: Part B
10X MOPS Buffer for molecular biology
68078
Sisco Laboratories
100 ml
EUR 4.5
Description: Part B
CHAPS Buffer for molecular biology, 99.5%
21420
Sisco Laboratories
1 Gms
EUR 10.73
Description: Part B
HEPES Buffer for molecular biology, 99.5%
16826
Sisco Laboratories
25 Gms
EUR 6.3
Description: Part B
Sodium Azide for molecular biology, 99%
17782
Sisco Laboratories
100 Gms
EUR 5.47
Description: Part A
Agarose High EEO for molecular biology
60645
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25 Gms
EUR 13.8
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Jasmonic Acid for molecular biology, 95%
79238
Sisco Laboratories
25 Mg
EUR 120.9
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Protamine Sulfate for molecular biology, 90-110%
78349
Sisco Laboratories
1 Gms
EUR 22.5
Description: Part B
Oil Red O for molecular biology, 75%
23576
Sisco Laboratories
25 Gms
EUR 5.33
Description: Part B
Agarose Medium EEO for molecular biology
10423
Sisco Laboratories
10 Gms
EUR 6.75
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Isopropanol (IPA) for molecular biology, 99.8%
38445
Sisco Laboratories
100 ml
EUR 1.71
Description: Part A
Sodium Chloride for molecular biology, 99.9%
33205
Sisco Laboratories
500 Gms
EUR 4.52
Description: Part A
Ethidium Bromide for molecular biology, 95%
93079
Sisco Laboratories
1 Gms
EUR 4.58
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Ammonium Acetate for molecular biology, 98%
37829
Sisco Laboratories
100 Gms
EUR 2.12
Description: Part A
Agarose Low Melting for molecular biology
32417
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5 Gms
EUR 22.5
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Acetonitrile (ACN) for molecular biology, 99.9%
62006
Sisco Laboratories
250 ml
EUR 4.93
Description: Part A
Potassium Acetate for molecular biology, 99.5%
96248
Sisco Laboratories
100 Gms
EUR 2.74
Description: Part A
Ammonium Sulphate for molecular biology, 99.5%
82126
Sisco Laboratories
250 Gms
EUR 4.93
Description: Part A
Ammonium Chloride for molecular biology, 99.5%
16992
Sisco Laboratories
500 Gms
EUR 4.52
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Potassium Chloride for molecular biology, 99.5%
84984
Sisco Laboratories
500 Gms
EUR 6.16
Description: Part A
Sodium Bicarbonate for molecular biology, 99.7%
36328
Sisco Laboratories
500 Gms
EUR 5.47
Description: Part A
Glycerol (Glycerine) for molecular biology, 99.5%
62417
Sisco Laboratories
100 ml
EUR 2.05
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Phenol Crystalline for molecular biology, 99.5%
17286
Sisco Laboratories
100 Gms
EUR 3.15
Description: Part A
Phenol, (Carbolic acid) Double distilled for Molecular Biology
PD0252
Bio Basic
500g
EUR 192.59
2-Mercaptoethanol for molecular biology, 99%
83759
Sisco Laboratories
100 ml
EUR 5.27
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Tetrahydrofuran (THF) for molecular biology, 99.8%
92562
Sisco Laboratories
250 ml
EUR 3.28
Description: Part A
Acriflavine Neutral for molecular biology, 98%
42428
Sisco Laboratories
5 Gms
EUR 3.15
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Dichloromethane (DCM) for molecular biology, 99.9%
41512
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250 ml
EUR 3.22
Description: Part A
Dithioerythritol (DTE) for molecular biology, 99%
53384
Sisco Laboratories
1 Gms
EUR 9.53
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HEPES Sodium Salt for molecular biology, 99%
32225
Sisco Laboratories
25 Gms
EUR 11.85
Description: Part B
meta-Topolin (mT) for molecular biology, 98%
68913
Sisco Laboratories
25 Mg
EUR 17.48
Description: Part B
L-Ascorbic Acid for molecular biology, 99.7%
14116
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25 Gms
EUR 1.64
Description: Part A
Glycogen ex. Oyster for molecular biology, 85%
49740
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1 Gms
EUR 7.5
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Acetic Acid Glacial for molecular biology, 99.9%
59788
Sisco Laboratories
100 ml
EUR 3.56
Description: Part A
D-Sorbitol Powder for molecular biology, 98%
99103
Sisco Laboratories
500 Gms
EUR 10.33
Description: Part A
Brilliant Blue R-250 for molecular biology
93473
Sisco Laboratories
5 Gms
EUR 4.35
Description: Part B
Acrylamide 3x cryst. for molecular biology, 99.9%
61346
Sisco Laboratories
100 Gms
EUR 5.47
Description: Part A
Brilliant Blue G-250 for molecular biology
64222
Sisco Laboratories
5 Gms
EUR 4.65
Description: Part B
Propidium Iodide (PI) for molecular biology, 95%
11195
Sisco Laboratories
10 Mg
EUR 17.63
Description: Part B
Acriflavine Hydrochloride for molecular biology, 98.5%-105%
35188
Sisco Laboratories
5 Gms
EUR 4.05
Description: Part B
Tris Buffer Superior for molecular biology, 99.9%
37969
Sisco Laboratories
100 Gms
EUR 7.59
Description: Part A
Polysorbate 20 (Tween 20) for molecular biology
65296
Sisco Laboratories
100 Gms
EUR 10.81
Description: Part A
Molecular Biology Grade Water for RT-PCR
ML065-1.5ML
EWC Diagnostics
1 unit
EUR 7.82
Description: Molecular Biology Grade Water for RT-PCR
10X TE Buffer pH-8.0 for molecular biology
51782
Sisco Laboratories
100 ml
EUR 9.45
Description: Part B
10X TBE Buffer pH-8.3 for molecular biology
83170
Sisco Laboratories
200 ml
EUR 4.95
Description: Part B
Tris Buffer AR, ACS for molecular biology, 99.9%
71033
Sisco Laboratories
100 Gms
EUR 6.02
Description: Part A
10X TAE Buffer pH-8.3 for molecular biology
71989
Sisco Laboratories
100 ml
EUR 4.43
Description: Part B
Acrylamide 40% aq. solution for molecular biology
29787
Sisco Laboratories
250 ml
EUR 20.53
Description: Part A
MES Monohydrate Buffer for molecular biology, 99%
26854
Sisco Laboratories
25 Gms
EUR 11.03
Description: Part B
DL-Dithiothreitol (DTT) for molecular biology, 98%
17315
Sisco Laboratories
1 Gms
EUR 5.18
Description: Part B
Glutathione Reduced (GSH) for molecular biology, 99.5%
11514
Sisco Laboratories
1 Gms
EUR 5.55
Description: Part B
Ammonium Persulphate (APS) for molecular biology, 99%
65553
Sisco Laboratories
25 Gms
EUR 1.64
Description: Part A
Trifluoroacetic Acid (TFA) for molecular biology, 99.9%
40801
Sisco Laboratories
100 ml
EUR 22.92
Description: Part A
Sodium Acetate Anhydrous for molecular biology, 99%
22342
Sisco Laboratories
250 Gms
EUR 3.56
Description: Part A
Dimethyl Sulphoxide (DMSO) for molecular biology, 99.8%
24075
Sisco Laboratories
100 ml
EUR 6.02
Description: Part A
Cesium Sulphate extrapure for molecular biology, 99.9%
57455
Sisco Laboratories
10 Gms
EUR 7.5
Description: Part B
Sodium Acetate Trihydrate for molecular biology, 99.5%
88035
Sisco Laboratories
250 Gms
EUR 2.33
Description: Part A
Cesium Chloride ultrapure for molecular biology, 99.9%
32355
Sisco Laboratories
25 Gms
EUR 18
Description: Part B
Guanidine Thiocyanate (GTC) for molecular biology, 99%
80272
Sisco Laboratories
100 Gms
EUR 5.47
Description: Part A
Glutathione Oxidized (GSSG) for molecular biology, 99.5%
22151
Sisco Laboratories
250 Mg
EUR 22.5
Description: Part B
Pyridine, GlenBiol™, suitable for molecular biology with molecular sieve
GS8780
Glentham Life Sciences
2500ml
EUR 239.63
Pyridine, GlenBiol™, suitable for molecular biology with molecular sieve
GS8780-2500
Glentham Life Sciences
2500
EUR 249.8
Calcium Chloride Dihydrate for molecular biology, 99.5%
97080
Sisco Laboratories
100 Gms
EUR 2.12
Description: Part A
Diethyl Pyrocarbonate (DEPC) for molecular biology, 99%
46791
Sisco Laboratories
5 ml
EUR 9
Description: Part B
20X SSC Buffer pH 6.9-7.1 for molecular biology
12590
Sisco Laboratories
200 ml
EUR 2.48
Description: Part B
Guanidine Hydrochloride (GHC) for molecular biology, 99.5%
45539
Sisco Laboratories
100 Gms
EUR 4.79
Description: Part A
Bromocresol Purple Sodium Salt for molecular biology
24836
Sisco Laboratories
5 Gms
EUR 2.05
Description: Part A
Polyethylene Glycol 8000 (PEG 8000) for molecular biology
54866
Sisco Laboratories
500 Gms
EUR 11.97
Description: Part A
10X Tris Buffered Saline (TBS) for molecular biology
83471
Sisco Laboratories
500 ml
EUR 14.7
Description: Part B
Magnesium Acetate Tetrahydrate for molecular biology, 99%
50488
Sisco Laboratories
100 Gms
EUR 2.74
Description: Part A
Magnesium Chloride Hexahydrate for molecular biology, 99.5%
91417
Sisco Laboratories
250 Gms
EUR 4.45
Description: Part A
Magnesium Sulphate Heptahydrate for molecular biology, 99.5%
74440
Sisco Laboratories
500 Gms
EUR 6.16
Description: Part A
Tris Hydrochloride (Tris HCl) for molecular biology, 99%
89781
Sisco Laboratories
100 Gms
EUR 9.37
Description: Part A
Agarose Low EEO Superior Grade for molecular biology
23287
Sisco Laboratories
10 Gms
EUR 6
Description: Part B
L-Lysine Monohydrate (base) for molecular biology, 99%
45976
Sisco Laboratories
25 Gms
EUR 37.63
Description: Part A
DTT (Molecular Biology Grade)
CE131
GeneOn
5 g
EUR 44
DTT (Molecular Biology Grade)
CE132
GeneOn
10 g
EUR 88
DTT (Molecular Biology Grade)
CE133
GeneOn
25 g
EUR 170
NAD (Molecular Biology Grade)
CE196
GeneOn
1 g
EUR 34
NAD (Molecular Biology Grade)
CE197
GeneOn
5 g
EUR 137
NBT (Molecular Biology Grade)
CE209
GeneOn
1 g
EUR 96
NBT (Molecular Biology Grade)
CE210
GeneOn
5 g
EUR 345
10X Tris-Glycine-SDS Buffer for molecular biology
57806
Sisco Laboratories
200 ml
EUR 3.6
Description: Part B
10X Tris-Tricine-SDS Buffer for molecular biology
37852
Sisco Laboratories
500 ml
EUR 9.08
Description: Part B
Cesium Chloride extrapure AR for molecular biology, 99.9%
22966
Sisco Laboratories
25 Gms
EUR 14.63
Description: Part B
N,N-Dimethylformamide (DMF) for molecular biology, 99.9%
24017
Sisco Laboratories
100 ml
EUR 3.08
Description: Part A
EDTA Disodium Salt Dihydrate for molecular biology, 99.5%
43272
Sisco Laboratories
100 Gms
EUR 2.26
Description: Part A
DMSO, Molecular Biology Grade
40470006-1
Bio-WORLD
100 mL
EUR 108.14
DMSO, Molecular Biology Grade
40470006-2
Bio-WORLD
250 mL
EUR 182.67
DMSO, Molecular Biology Grade
40470006-3
Bio-WORLD
500 mL
EUR 342.49
EGTA, Molecular Biology Grade
40500028-2
Bio-WORLD
50 g
EUR 130.53
EGTA, Molecular Biology Grade
40500028-3
Bio-WORLD
100 g
EUR 217.78
EGTA, Molecular Biology Grade
40500028-4
Bio-WORLD
500 g
EUR 734.55
EGTA, Molecular Biology Grade
40500028-5
Bio-WORLD
1 kg
EUR 1119.67
EGTA, Molecular Biology Grade
40500028-6
Bio-WORLD
2 kg
EUR 2070.09
BCIP (Molecular Biology Grade)
CE108
GeneOn
250 mg
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BCIP (Molecular Biology Grade)
CE109
GeneOn
1 g
EUR 82
DAPI (Molecular Biology Grade)
CE117
GeneOn
5 mg
EUR 40
DAPI (Molecular Biology Grade)
CE118
GeneOn
25 mg
EUR 133
DAPI (Molecular Biology Grade)
CE119
GeneOn
100 mg
EUR 281
Tris (Molecular Biology Grade)
CE237
GeneOn
500 g
EUR 79
Tris (Molecular Biology Grade)
CE238
GeneOn
1 kg
EUR 135
Tris (Molecular Biology Grade)
CE239
GeneOn
5 kg
EUR 608
Dimethylformamide, GlenBiol™, suitable for molecular biology with molecular sieve
GS3406
Glentham Life Sciences
2500ml
EUR 111.53
Dimethylformamide, GlenBiol™, suitable for molecular biology with molecular sieve
GS3406-2500
Glentham Life Sciences
2500
EUR 116.2
Chloroform : Isoamyl Alcohol (24:1) for molecular biology
85563
Sisco Laboratories
100 ml
EUR 8.48
Description: Part B
1X Phosphate Buffered Saline (PBS) for molecular biology
95131
Sisco Laboratories
100 ml
EUR 3.98
Description: Part B
Saponin ex. Quillaja for molecular biology, 9% Sapogenin
80967
Sisco Laboratories
25 Gms
EUR 45
Description: Part B
CHAPS (Molecular Biology Grade)
CE114
GeneOn
1 g
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CHAPS (Molecular Biology Grade)
CE115
GeneOn
5 g
EUR 97
CHAPS (Molecular Biology Grade)
CE116
GeneOn
25 g
EUR 319
HEPES (Molecular Biology Grade)
CE171
GeneOn
100 g
EUR 40
HEPES (Molecular Biology Grade)
CE172
GeneOn
500 g
EUR 162
HEPES (Molecular Biology Grade)
CE173
GeneOn
1 kg
EUR 285
Water (Molecular Biology Grade)
CE243
GeneOn
500 ml
EUR 62.4
Water (Molecular Biology Grade)
CE244
GeneOn
1 l
EUR 35
Molecular Biology Grade Water
ML024-100ML
EWC Diagnostics
1 unit
EUR 3.54
Description: Molecular Biology Grade Water
Molecular Biology Grade Water
ML024-10X100ML
EWC Diagnostics
1 unit
EUR 29.52
Description: Molecular Biology Grade Water
Molecular Biology Grade Water
ML024-10X500ML
EWC Diagnostics
1 unit
EUR 87.91
Description: Molecular Biology Grade Water
Molecular Biology Grade Water
ML024-500ML
EWC Diagnostics
1 unit
EUR 12.56
Description: Molecular Biology Grade Water
Molecular Biology Grade Water
ML064-100ML
EWC Diagnostics
1 unit
EUR 3.67
Description: Molecular Biology Grade Water
Molecular Biology Grade Water
ML064-10X100ML
EWC Diagnostics
1 unit
EUR 25.38
Description: Molecular Biology Grade Water
Molecular Biology Grade Water
ML064-500ML
EWC Diagnostics
1 unit
EUR 10.81
Description: Molecular Biology Grade Water
10X Phosphate Buffered Saline (PBS) for molecular biology
78529
Sisco Laboratories
100 ml
EUR 4.95
Description: Part B
Potassium Dihydrogen Orthophosphate for molecular biology, 99.5%
54358
Sisco Laboratories
250 Gms
EUR 4.11
Description: Part A
Dimethylformamide, GlenBiol™, suitable for molecular biology
GS6580-2500
Glentham Life Sciences
2500
EUR 107.3
Glycin (Molecular Biology Grade)
CE158
GeneOn
1 kg
EUR 61
Glycin (Molecular Biology Grade)
CE159
GeneOn
5 kg
EUR 221
OORA00218-100IU - DNA Ligase T4 Molecular Biology Grade
OORA00218-100IU
Aviva Systems Biology
100Units
EUR 129
DEAE Cellulose 52 analytical grade for molecular biology
10529
Sisco Laboratories
5 Gms
EUR 16.28
Description: Part B
EDTA Tetrasodium Salt Dihydrate for molecular biology, 99.5%
45247
Sisco Laboratories
100 Gms
EUR 6.16
Description: Part A
DEAE Cellulose 23 analytical grade for molecular biology
57136
Sisco Laboratories
5 Gms
EUR 20.7
Description: Part B
DEAE Cellulose 32 analytical grade for molecular biology
92321
Sisco Laboratories
5 Gms
EUR 25.73
Description: Part B
DEAE Cellulose 11 analytical grade for molecular biology
47478
Sisco Laboratories
5 Gms
EUR 18.38
Description: Part B
20X SSPE Buffer pH-7.4 suitable for molecular biology
78305
Sisco Laboratories
200 ml
EUR 6.75
Description: Part B
HEPES Buffer 1M Solution pH-7.3 for molecular biology
78805
Sisco Laboratories
100 ml
EUR 25.2
Description: Part B
Agarose, Molecular Biology Grade
40100164-1
Bio-WORLD
25 g
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Agarose, Molecular Biology Grade
40100164-2
Bio-WORLD
50 g
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Agarose, Molecular Biology Grade
40100164-3
Bio-WORLD
100 g
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Agarose, Molecular Biology Grade
40100164-4
Bio-WORLD
500 g
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Agarose, Molecular Biology Grade
40100164-5
Bio-WORLD
1 kg
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Agarose (Molecular Biology Grade)
abx299715-100g
Abbexa
100 µg
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Agarose (Molecular Biology Grade)
abx299715-20g
Abbexa
20 µg
EUR 525
Agarose (Molecular Biology Grade)
abx299715-50g
Abbexa
50 µg
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5-Fluoroorotic Acid (5-FOA) for molecular biology, 98%
78510
Sisco Laboratories
250 Mg
EUR 29.78
Description: Part B
Lysozyme (Molecular Biology Grade)
CE188
GeneOn
1 g
EUR 70.8
Lysozyme (Molecular Biology Grade)
CE189
GeneOn
10 g
EUR 80
Lysozyme (Molecular Biology Grade)
CE189L
GeneOn
50 g
EUR 310
Lysozyme (Molecular Biology Grade)
CE189XL
GeneOn
250 g
EUR 1050
Sodium Citrate Tribasic Dihydrate for molecular biology, 99%
67331
Sisco Laboratories
250 Gms
EUR 4.38
Description: Part A
RESULTS causal diagram representing knowledge and tools integrated seed for their future development and the development of a similar diagram for other environment-related diseases such as asthma or infertility. In this paper the development and implementation of a causal diagram for cancer are presented and discussed.