BACKGROUND The development of graphical / visual presentation of the etiology of cancer caused by environmental stress is a process that requires incorporating biological interactions complex between xenobiotics in living and working environment with the gene (gene-environment interactions) and the mechanisms of certain diseases based on genomic and non-genomic in life organism. Traditionally, presentation causal relationships including statistical association between exposure to a xenobiotic and diseases corrected for the effect of potential confounders.
METHOD In HENVINET FP6 project, we aim to consider the agent together all the known and the mechanisms involved in the development of selected types of cancer. Selection of the type of cancer to the causal diagram based on the corpus of data available and reported relative risk (RR). In establishing a causal diagram complexity of interactions between xenobiotics considered as a priority in the interpretation of the risk of cancer. In addition, gene-environment interactions such as polymorphism gene inserted to repair and Phase I and II enzymes involved in the metabolism of xenobiotics and their elimination. Information about the possibility of age or gender vulnerability is also included.
Diagram user friendly thanks to access to the stage for an information packet and referring to the relevant literature and a glossary of terms. Diagram cover both the chemical and physical agents (ionizing and non-ionizing radiation) and provide basic information about the strength of the relationship between the types of exposures and cancer risk were reported by human studies and is supported by mechanistic studies. Causal diagram HENVINET developed in the project is a valuable source of information for professionals working in the field of environmental health and epidemiology, and as an educational material for students.
Cancer risk and the complexity of the interactions between environmental and host factors: HENVINET interactive diagrams as simple tools for exploring and understanding the scientific evidence.
BACKGROUND Cancer risk results from a complex interaction of environmental exposure with polymorphisms of genes are inherited, genetic load collected during development and capacity non-genomic response to environmental insults. In order to adopt preventive measures are effective and relevant regulatory measures, a comprehensive investigation of the etiology of cancer is very important. Variations and fluctuations in the incidence of cancer in the human population does not reflect the policy of environmental pollution or population distribution of genetic polymorphisms known to be associated with an increased risk of cancer.
Tools that can be used in such comprehensive research, including molecular biology applied to field studies, requires a shift methodological reductionism that has been used until recently as a basic axiom in the interpretation of data. The complexity of interactions between cells, genes and environment, the resonance of living matter with the environment, can be synthesized by biological systems. In the philosophy HENVINET project followed in order to develop interactive causal diagram for cancer investigation with a possible etiology in environmental exposures.
2-Mercaptoethanol ?For Molecular Biology
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"10X PBS, Molecular Biology Grade"
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CE145
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CE154
GeneOn
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CE194
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100 g
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CE240
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OORA00219-v1 - DNA Ligase T4 Molecular Biology Grade (500units)
OORA00219-v1
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GeneOn
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GeneOn
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CE167
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CE155
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250 g
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500 g
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CE236
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CE250
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100 mg
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GeneOn
500 mg
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OORA00219-500UNITS
Aviva Systems Biology
500Units
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NADP - sodium salt (Molecular Biology Grade)
CE200
GeneOn
250 mg
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NADP - sodium salt (Molecular Biology Grade)
CE201
GeneOn
1 g
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Guanidine Thiocyanate (Molecular Biology Grade)
CE164
GeneOn
100 g
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CE165
GeneOn
500 g
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Guanidine Thiocyanate (Molecular Biology Grade)
CE166
GeneOn
1 kg
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NADH - Disodium salt (Molecular Biology Grade)
CE198
GeneOn
1 g
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NADH - Disodium salt (Molecular Biology Grade)
CE199
GeneOn
5 g
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Agarose Powder 100g -Molecular Biology Grade
MB755-0100
Bio-Helix
100 g
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Agarose Powder 500g -Molecular Biology Grade
MB755-0500
Bio-Helix
500 g
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Guanidine - Hydrochloride (Molecular Biology Grade)
CE160
GeneOn
100 g
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CE161
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GeneOn
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GeneOn
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CE150
GeneOn
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Yeast extract powder (Molecular Biology Grade)
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GeneOn
500 g
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CE170
GeneOn
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Di-iso-propylethylamine, GlenBiol™, suitable for molecular biology
GS7181-100
Glentham Life Sciences
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GS7181-500
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500
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250
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Hyaluronidase Grade I (Molecular Biology Grade)
CE174
GeneOn
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CE175
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GeneOn
500 mg
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GX7489-1
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GX7489-2500
Glentham Life Sciences
2500
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Glentham Life Sciences
500
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2500
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250
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250
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Albumin fraction V (pH7,0) (Molecular Biology Grade)
CE100
GeneOn
50 g
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Albumin fraction V (pH7,0) (Molecular Biology Grade)
CE101
GeneOn
100 g
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Albumin fraction V (pH7,0) (Molecular Biology Grade)
CE102
GeneOn
250 g
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Albumin fraction V (pH7,0) (Molecular Biology Grade)
CE103
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500 g
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Albumin fraction V (pH7,0) (Molecular Biology Grade)
CE104
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EDTA - Dinatriumsalz - Dihydrat (Molecular Biology Grade)
CE135
GeneOn
250 g
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EDTA - Dinatriumsalz - Dihydrat (Molecular Biology Grade)
CE136
GeneOn
500 g
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EDTA - Dinatriumsalz - Dihydrat (Molecular Biology Grade)
CE137
GeneOn
1 kg
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EDTA - Dinatriumsalz - Dihydrat (Molecular Biology Grade)
CE138
GeneOn
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TRIS-Glycine-SDS Buffer 10X, GlenBiol™, suitable for molecular biology
GE9118-1
Glentham Life Sciences
1
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TRIS-Glycine-SDS Buffer 10X, GlenBiol™, suitable for molecular biology
GE9118-250
Glentham Life Sciences
250
EUR 30.1
RESULTS causal diagram representing knowledge and tools integrated seed for their future development and the development of a similar diagram for other environment-related diseases such as asthma or infertility. In this paper the development and implementation of a causal diagram for cancer are presented and discussed.